Upper Rhine
Immunology Group




Trüb et al., 2020, Journal of Immunotherapy of Cancer: Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer

Schwabenland/Salie et al., 2021, preprint dx.doi.org/10.2139/ssrn.3765620 Deep spatial profiling of COVID19 brains reveals neuroinflammation by compartmentalized local immune cell interactions and targets for intervention

Swarnalekha et al., 2021, Science Immunology: T resident helper cells promote humoral responses in the lung

Julien, E., Biasch, K., El Omar, R., Freund, J.N., Gachet, C., Lanza, F., and Tavian, M., 2021, Stem Cells: Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells

Kury, Staniek et al., 2021, Journal Allergology Clinical Immunol: JACI Agammaglobulinemia with normal B-cell numbers in a patient lacking Bob1

Lösslein A et al., 2021, Nature Communications: Monocyte progenitors give rise to multinucleated giant cells

Sehnert B, Mietz J, Rzepka R, Buchholz S, Voll RE, 2021, Int J Mol Sci.: Neuraminidase inhibitor zanamivir ameliorates collagen-induced arthritis

Hensel et al., 2021, Nature Immunology: Memory-like HCV specific CD8+ T cell retain a chronic scar after cure of HCV infection

Maccari et al., 2021, J Exp Med.: A distinct CD38+ CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS

Bernardi et al., 2021, Proc Natl Acad Sci.: CD4+ T cells require Ikaros to inhibit their differentiation towards a pathogenic cell fate



Künzli et al., 2020, Science Immunology: Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity

Fallet et al. Chronic, 2020, Cell Rep.: Viral Infection Promotes Efficient Germinal Center B Cell Responses

Vacchini et al., 2020, Frontiers in Immunology: MR1-Restricted T Cells Are Unprecedented Cancer Fighters

Kolb et al., 2020, bioRxiv: Human Cytomegalovirus antagonizes activation of Fcγ receptors II and III by distinct and synergizing modes of IgG manipulation

Chen et al., 2020, bioRxiv: Immune complex solubility and size govern Fc-gamma receptor responses

Doelz et al., 2020, bioRxiv.org: The non-coding RNA miR-17-92 is a central mediator of T cell activation

Bornert A, Boscher J, Pertuy F, Eckly A, Stegner D, Strassel C, Gachet C, Lanza F, Léon C, 2020, Haematologica: Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

Hartl et al., 2020, Nature Immunology: Noncanonical binding of Lck to CD3e promotes TCR signaling and CAR function



Angénieux C. et al., 2019, Journal of Thrombosis and Hemostasis, Cell surface expression of HLA I molecules as a marker of young platelets

El Mdawar MB. et al., 2019, Scientific Reports The ATP-gated P2X1 ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice

Tangye et al., 2019, Immunol Cell Biol

Camara et al., 2019, Immunity : Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche

Mattes et al., 2019, Adv. Mat.: Review solid material based synthesis

Brokatzky D. et al., 2019, EMBO J.

Kolter J et al., 2019: Immunity: A subset of skin macrophages contributes to the surveillance and regeneration of local nerves

Alfei et. al., 2019: Nature: TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Voisin B, […] Flacher V, Mueller CG, 2019: BioRxiv: The hair cycle underlies regulation of Langerhans cell renewal

Baeuerle et al., 2019: Nature Communications: Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response



Thommen et al., 2018, Nature Medicine: A transcriptionally and functionally distinct PD-1 + CD8 + T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

Bengsch et al. 2018, Immunity: Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

Unger et al., 2018, JACI: TH1 phenotype of T follicular helper cells indicates an IFNgamma-associated immune dysregulation in CD21low CVID patients

Klocperk et al., 2018, JACI: Exhausted phenotype of follicular CD8 T cells in CVID

Kornete et al., 2018, Journal of Immunology: Highly Efficient and Versatile Plasmid-based Gene Editing in Primary T Cells

M. Schmaler et al., 2018, Mucosal Immunol 11: Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation

Heizmann et al., 2018, Current opinion in Immunology: The Ikaros family in lymphocyte development

Muller Q, […] Flacher V, Berthod F., 2018, Acta Biomater: Development of an innervated tissue-engineered skin with human sensory neurons and Schwann cells differentiated from iPS cells



Onder et al., 2017, Immunity 47: Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis

M. Lepore et al., 2017, Elife 6: Functionally diverse human T cells recognize non-microbial antigens presented by MR1

Schneider K et al., 2017, Cell Reports: The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity

M. Lepore et al., 2017, Elife 6: Functionally diverse human T cells recognize non-microbial antigens presented by MR1

Katz et al., 2017, Nature Immunology: A cycle of kinase activation and release at the T-cell receptor amplifies and disperses antigenic stimuli



Fallet et al., 2016, Sci Immunol: Interferon-driven deletion of antiviral B cells at the onset of chronic infection

Löffler et al., 2016, Nat. Comm.: nano3D printer

Janda et al., 2016, Blood: Disturbed B-lymphocyte selection in autoimmune lymphoproliferative syndrome

Aguilar A, Pertuy F, Eckly A, Strassel C, Collin D, Gachet C, Lanza F, Léon C, 2016, Blood: Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation

Gross CJ et al., 2016 Immunity: A mitochondrial target of imiquimod is involved in Nlrp3 inflammasome activation and cancer cell growth arrest

Matzke-Ogi et al., 2016, Gastroenterology: Inhibition of Tumour growth and metastasis in pancreatic cancer by interference with CD44v6 signaling

Y.S. Hu et al., 2016, PNAS: Superresolution imaging reveals nanometer- and micrometer-scale spatial distributions of T-cell receptors in lymph nodes



Kögl T et al., 2013, Blood: Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease



Vince JE et.al., 2012, Immunity

Sinka L, Biasch K, Khazaal I, Peault B, Tavian M., 2012, Blood: Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo

Morath et al., 2018, Oncogene: Differential recruitment of CD44 isoforms by ErbB ligands reveals an involvement of CD44 in breast cancer



eubert K, Meister S, Moser K, Weisel F, Voll RE, 2008, Nat Med.: The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis